Bolgatanga Nursing Training College was established in the 1950s for the training of Enrolled Nurses and Midwives (auxillary nurses), Qualified Registered Nurses and Midwives. Historically, the Nursing Training College and the Midwifery Training College shared the same umbilical cord. As the health needs of the region and country as whole started increasing due to increase in population, there was the need to separate the School into two, the Nursing Training College, the Bolgatanga and Midwifery Training College, Bolgatanga. Hence the relocation of Bolgatanga Nursing Training College to its current location on the Friday, 20th of April, 1990. The current facilities in the school were meant for laboratories for the Regentropfen College of Applied science (ReCAS) proposed by the then government in the 1970s. The philosophy of the ReCAS program was that good and quality education should not be the preserve of the rich in society but should also be accessible to the poor and marginalized, hence the establishment of the program.
In 20th April 1990, the first batch of nine (9) students of the Comprehensive Nursing State Registered Nursing commenced and in 1992 the second batch of 13 students were also admitted. The State Registered Nursing program continued until in 1999 when the Registered General Nursing Diploma was introduced. Currently, the School runs the Registered General Nursing program and has train a lot of nurses all occupying various positions and capacities and contributing their quota to mother Ghana. The College is affiliated to the Kwame Nkrumah University of Science and Technology. The College has been regarded as an outstanding provider of Diploma Nursing Education in the Upper East Region and the entire country.